TIARA

The TIARA study is a national, multi-centre, hospital-based, prospective, observational study. Patient recruitment will take place at eight German university hospitals. Throughout the study, a cohort of 1,200 complex surgical patients undergoing open pancreaticoduodenectomy or open rectum/colon resection will be established including in-depth data collection and biomaterial sampling from different body sites at different timepoints pre- and post-surgery. 
Moreover, a national Antimicrobial Stewardship (AMS) Board, consisting of AMS experts and/or Infectious Disease (ID) specialists from all partner sites, will rate the quality of diagnostic and therapeutic measures related to the anti-infective treatments of study patients. 
Long-term outcome parameters will be assessed up to two years following the surgery. As an optional substudy, the quality of life will be assessed in included patients at different time points.