Temporal and Regional Trends in Systemic Anti-Cancer Treatments

This project investigates systemic anticancer therapies in older adults through a transatlantic comparison between Germany and the United States. The aim is to analyse treatment sequences for curative and palliative therapies in the ten most incident solid cancers (lung, prostate, breast, colorectal, bladder, pancreatic, kidney, gastric, oesophageal, and endometrial) using real-world data (RWD). Differences and similarities in treatment patterns, drug regimens, and clinical outcomes will be examined to generate insights for optimising care strategies for ageing populations.

In Germany, a multicentre approach is applied: tumour documentation data are accessed via the Clinical Communication Platform (CCP) of the German Cancer Consortium (DKTK). Analyses are conducted with the federated software DataSHIELD, ensuring that patient data remain within each centre. Only aggregated results are compared across countries.

Type of participation: Overall coordination and project lead in Germany

Funding status: No external funding.